ODOQuiz - One Day One Question

02 September 2025

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1. Describe clinical and radiological findings

Multiple fractures, blue sclera

2. Pathophysiology?

Mutations in genes responsible for synthesis or processing of type I collagen a crucial protein for bone strength and other connective tissues.

3. What is the dx? differential dx?

Osteogenesis imperfecta, non accidental injury

4. Mention the differentiations between the main dx and DD? Any three

Ol Vs. Child Abuse

Findings Osteo. Imp. Abuse
Incidence Rare Common
Positive family history Common Common
Blue Sclera Common Rare
Abnormal teeth Common Rare
Hearing problems Common Uncommon
Osteoporosis Common Rare
Abnormal fracture healing Common Rare
Wormian bones Common Rare
Joint laxity Common Rare
Short stature Common Occasionally
Fracture recurrence Common Rare
In utero fracture Common Rare