ODOQuiz - One Day One Question

Quiz.no 15 -13 September 2025

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This eight year old boy complains of headache, lasting for last 3 months. No history of trauma. CNS exam including fundus was normal. Locallized tenderness noticed on the parietal side. No swelling. CT skull is enclosed
1. Radiological finding

Single/Multiple skull lesions

2. Probable clinical dx?

Langerhans cell histiocytosis former name histiocytosis x CLCH

3. Pathophysiology?

V600 E Mutation Braf Gene, neoplastic disorder, though it doesn’t behave like a malignant fashion, originating from myeloid cell precursor.

4. Specific Microscopic (EM) findings

Sp. Microscopy: Coffee bean–shaped nuclei [EM], Birbeck granules (tennis racket appearance)